5.1 Use a chi-square test to determine if each of the following pairs of loci are in linkage equilibrium, given observed two-locus genotype counts (critical value = 9.488):
a)
| AA | Aa | aa | |
| BB | 25 | 10 | 10 |
| Bb | 50 | 30 | 20 |
| bb | 50 | 20 | 30 |
b)
| AA | Aa | aa | |
| BB | 60 | 35 | 5 |
| Bb | 120 | 74 | 9 |
| bb | 60 | 34 | 6 |
c)
| AA | Aa | aa | |
| BB | 6 | 11 | 7 |
| Bb | 12 | 25 | 15 |
| bb | 5 | 13 | 7 |
d)
| AA | Aa | aa | |
| BB | 1 | 10 | 14 |
| Bb | 40 | 5 | 5 |
| bb | 6 | 8 | 16 |
5.2 Calculate the coefficient of disequilibrium, D, given haplotype frequencies.
a)
| f(AB) | f(Ab) | f(aB) | f(ab) |
| 0.2 | 0.2 | 0.4 | 0.2 |
b)
| f(AB) | f(Ab) | f(aB) | f(ab) |
| 0.0 | 0.3 | 0.4 | 0.3 |
c)
| f(AB) | f(Ab) | f(aB) | f(ab) |
| 0.1 | 0.1 | 0.4 | 0.4 |
d)
| f(AB) | f(Ab) | f(aB) | f(ab) |
| 0.25 | 0.2 | 0.15 | 0.4 |